Risk factors and development of an early screener in type 1 diabetes

Evaluation of an early screener to identify long-term problems with regard to metabolic control and treatment adherence among children and adolescents with type 1 diabetes


Principal investigators: Prof. Dr. M. Landolt, Prof. Dr. D. Konrad,

Funding: Diabetes Stiftung; Wolfermann-Nägeli Stiftung; Forschungszentrum für das Kind (FZK)

Duration of project: October 2017 – December 2021

 

Type 1 diabetes is one of the most common chronic illnesses among children and adolescents. Although, intensive medical care is provided for these patients, some of them have poor metabolic control. For example, only 21% of adolescents with type 1 diabetes in the USA achieve the recommended average blood sugar concentration (HbA1c<7.5%). This is a major problem, since chronic hyperglycemia is the primary cause of morbidity and mortality in type 1 diabetes and causes several serious complications, for example kidney failure, blindness, and stroke. Therefore, the International Society for Pediatric and Adolescent Diabetes (ISPAD) declared psychosocial factors, to be the most important risk factors of poor type 1 diabetes management. Therefore, an instrument is needed to identify children and adolescents with poor metabolic control in their course of disease as soon as possible. With an early identification of such risk patients, better support can be provided. However, there is no such instrument yet for pediatric patients with type 1 diabetes. To fill this gap, a questionnaire (FEPB) based on the PAT 2.0© (an instrument used in oncology) was developed for this project.

The aim of this project is to evaluate and validate a new instrument (FEPB) for an early identification of children and adolescents with poor metabolic control in their course of disease in a longitudinal design.

The sample consists of children and adolescents (age: 5–18 years), who were newly diagnosed with type 1 diabetes (2-4 weeks ago), and who are in care at the University Children’s Hospital of Zurich. Structured interviews are conducted with the patients and the parents are asked to fill out some questionnaires at two times: first, 2-4 weeks after the diagnosis (T1) and second 6 month later (T2). With the new instrument (FEPB) a risk score can be calculated for each patient at T1. Statistical analysis will be performed to determine whether that risk score can predict which patients have poor metabolic control (HbA1c > 7.5%) at T2.


Contact: fiona.mahler@kispi.uzh.ch

 

Risk factors of metabolic control in children and adolescents with type 1 diabetes

 

Principal investigators: Prof. Dr. M. Landolt, Prof. Dr. D. Konrad,

Funding: Diabetes Stiftung; Wolfermann-Nägeli Stiftung; Forschungszentrum für das Kind (FSK)

Duration of project: October 2017 – September 2020

 

Type 1 diabetes is one of the most common chronic illnesses among children and adolescents. Although, intensive medical care is provided for these patients, some of them have poor metabolic control. For example, only 21% of adolescents with type 1 diabetes in the USA achieve the recommended average blood sugar concentration (HbA1c<7.5%). This is a major problem, since chronic hyperglycemia is the primary cause of morbidity and mortality in type 1 diabetes and causes several serious complications, for example kidney failure, blindness, and stroke. Therefore, the International Society for Pediatric and Adolescent Diabetes (ISPAD) declared psychosocial factors, to be the most important risk factors of poor type 1 diabetes management.

The aim of this project is to determine the most important risk factors for poor metabolic control in children and adolescents with type 1 diabetes in a cross-sectional design.

The sample consists of children and adolescents (school age: 7–18 years), who were diagnosed with type 1 diabetes over a year ago, and who are in care at the University Children’s Hospital of Zurich. Structured interviews are conducted with the patients and the parents are asked to fill out some questionnaires. Additionally, hair samples are collected to investigate the cortisol levels of the past 3 months. The collected data is used to investigate the impact of different psychosocial risk factors including personality and self-efficacy of the patients, stress, social support, family environment, education, and parental factors on the metabolic control (HbA1c) in pediatric patients.


Contact: fiona.mahler@kispi.uzh.ch